Adverse Outcome Pathways (AOPs) Oriented Approach to Assess In Vitro Hazard of Silica and Lignin Nanomaterials Derived from Biomass Residues.

ABSTRACT: Bio-based nanomaterials (B-NMs), such as silica oxide (SiO₂)- and lignin (Lig)- based nanoparticles (NPs) derived from biomass waste, have gained attention in the last few years in the view of promoting the sustainability principles in several applications. However, scarce data are available about their safety. Thus, a hazard-testing strategy was designed considering as a reference the safe-and-sustainable-by-design (SSbD) framework for chemicals and materials, prioritizing the use of new approach methodologies (NAMs), such as in vitro and adverse outcome pathways (AOPs) approaches, for generating data about the potential hazard of B-NMs. Literature research was performed to identify the adverse outcomes (AOs) related to the selected B-NMs. All the AOPs investigated shared at le

SUBMITTER: Bengalli RD 

PROVIDER: S-EPMC11990304 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature