Antiviral Activity of Halogenated Compounds Derived from L-Tyrosine Against SARS-CoV-2.

ABSTRACT:

Introduction

Currently, there are no effective medications for treating all the clinical conditions of patients with COVID-19. We aimed to evaluate the antiviral activity of compounds derived from L-tyrosine against the B.1 lineage of SARS-CoV-2 in vitro and in silico.

Methodology

The cytotoxicities of 15 halogenated compounds derived from L-tyrosine were evaluated in Vero-E6 cells by the MTT assay. The antiviral activity of the compounds was evaluated using four strategies, and viral quantification was performed by a plaque assay and qRT-PCR. The toxicity of the compounds was evaluated by ADMET predictor software. The affinity of these compounds for viral or cellular proteins and the stability of their conformations were determined by docking and molecular dynamics, respect

SUBMITTER: Velasquez-Bedoya PA 

PROVIDER: S-EPMC11990460 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature