Arene Substitutions in Orchid Bibenzyls: Mechanistic Insights into Glucose Uptake and Lipid Metabolism for Targeting Metabolic Disorders.

ABSTRACT:

Background

Phytochemicals possess diverse therapeutic potential; however, the impact of arene substitutions on the pharmacological properties of the bibenzyl compounds batatasin III and gigantol, derived from Dendrobium venustum, remains unexplored.

Objectives

This study examines how structural differences between these compounds affect cellular glucose uptake and lipid metabolism during adipocyte differentiation.

Methods

The effects of both bibenzyl compounds on cytotoxicity and glucose uptake were assessed in mouse and human pre-adipocytes and rat skeletal muscle myoblasts using colorimetric assays. Lipid metabolism was evaluated through Oil Red O staining and quantification of triglyceride and glycerol levels, while protein and gene expression during adipocy

SUBMITTER: Nuamnaichati N 

PROVIDER: S-EPMC11990513 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature