The Effect of Polyethylene Terephthalate Nanoplastics on Amyloid-β Peptide Fibrillation.

ABSTRACT: Exposure of organisms to nanoplastics (NPs) is inevitable given their global abundance and environmental persistence. Polyethylene terephthalate (PET) is a common plastic used in a wide range of products, including clothing and food and beverage packaging. Recent studies suggest that NPs can cross the blood-brain barrier and cause potential neurotoxicity. It is widely known that aggregation of amyloid beta (Aβ) peptides in the brain is a pathological hallmark of Alzheimer's disease (AD). While the impact of nanoplastics such as polystyrene (PS) on amyloid aggregation has been studied, the effects of PET NPs remain unexplored. In this study, we examined the effect of PET NPs of different sizes (PET_50nm and PET_140nm) and concentrations (0, 10, 50, and 100 ppm) on the fi

SUBMITTER: Bashirova N 

PROVIDER: S-EPMC11990616 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature