Developmental trajectory of voluntary alcohol consumption in adolescent mice using finite mixture modeling and Bayesian posterior probability analysis.

ABSTRACT:

Background

Alcohol use disorders (AUDs) pose a significant public health challenge, with adolescence representing a critical period of vulnerability for the initiation of alcohol consumption. Variability in drinking behaviors among individuals complicates efforts to characterize developmental trajectories, limiting our understanding of underlying biological mechanisms.

Objective

This study aimed to identify and characterize distinct patterns of voluntary alcohol consumption in adolescent mice, using advanced statistical methods to model behavioral heterogeneity.

Methods

Thirty-five male CD-1 outbred mice were monitored for alcohol consumption using a two-bottle free-choice paradigm from early adolescence to young adulthood (4-11 weeks of age). Finite mixture modeling,

SUBMITTER: Yu N 

PROVIDER: S-EPMC11990736 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature