Aggregation-Induced Luminescent 3-Phenylpyrano[4,3-b]quinolizine Derivatives as Photosensitizers with Anti-Cancer Properties.

ABSTRACT: Photodynamic therapy (PDT) has garnered significant attention as an effective and safe method for cancer therapy, with ongoing efforts to develop new photosensitizers to enhance its efficacy. This study aimed to develop novel photosensitizers with aggregation-induced emission enhancement (AIEE) properties. A series of 3-phenyl pyrano[4,3-b]quinolizine compounds (3-10) were synthesized by reacting pyrones (1a-e) with 2-pyridylacetate (2a) or 2-pyridylacetonitrile (2b) and then evaluated for their potential as photosensitizers. Spectroscopic analyses revealed that all compounds emitted blue to green fluorescence in ethanol, with emission wavelengths ranging from 446 nm to 515 nm. Compounds 5 and 6, lacking a substituent at position 5 of

SUBMITTER: Hagimori M 

PROVIDER: S-EPMC11990754 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature