Protein <i>O</i>-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals.

ABSTRACT: Domain-specific O-fucosylation is an unusual type of glycosylation, where the fucose is directly attached to the serine or threonine residues in specific protein domains via an O-linkage. O-fucosylated proteins play critical roles in a wide variety of biological events and hold important therapeutic values, with the most studied being the Notch receptors and ADAMTS proteins. O-fucose glycans modulate the function of the proteins they modify and are closely associated with various diseases including cancer. In mammals, alongside the well-documented protein O-fucosyltransferase (POFUT) 1-mediated O-fucosylation of epidermal growth factor-like (EGF) repeats and POFUT2-mediated O-fucosylation of thrombospondin type 1 repeats (TSRs), a new type o

SUBMITTER: Hao H 

PROVIDER: S-EPMC11990869 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature