Anticandidal Activity of Lipopeptides Containing an LL-37-Derived Peptide Fragment KR12.

ABSTRACT: Candidiasis belongs to common fungal infections and is usually mild and self-limiting. However, in patients with immunodeficiencies, it can transform into invasive infections with high mortality. Long-term antifungal treatment can lead to the emergence of resistance. The problem is further complicated by the development of fungal biofilm resistant to conventional antimicrobials. Due to a limited choice of available antifungals, the development of novel active agents, such as antimicrobial peptides (AMPs), is highly desirable. Human cathelicidin LL-37 is an intensively studied AMP with a confirmed broad spectrum of antimicrobial activities. Due to the relatively high costs of production, the design of shorter analogs of LL-37 has been recommended. In this study, we synthesized a KR12 amide,

SUBMITTER: Paduszynska MA 

PROVIDER: S-EPMC11990879 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature