T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort.

ABSTRACT: Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection globally. Understanding natural immunity to CT will inform vaccine design. This study aimed to profile immune cells and associated functional features in CT-infected women and determine immune profiles associated with reduced risk of ascended endometrial CT infection and CT reinfection. PBMCs from CT-exposed women were profiled by mass cytometry, and random forest models identified key features that distinguished outcomes. CT+ participants exhibited higher frequencies of CD4+ Th2, Th17, and Th17 double-negative (Th17 DN) CD4+ T effector memory (TEM) cells than uninfected participants with decreased expression of T cell activation and differentiation markers. Minimal differences were detected between wome

SUBMITTER: Yount KS 

PROVIDER: S-EPMC11991011 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature