Molecular Mechanisms of Action of Dendrimers with Antibacterial Activities on Model Lipid Membranes.

ABSTRACT: In the last decades, numerous dendrimers with a variety of potential biomedical applications have been developed and investigated. The aim of the present study was to evaluate the molecular mechanisms of interaction between two dendrimers with proven antibacterial activity (4-N,N-dimethylamino-1,8-naphthalimide (Dab) and 3-bromo-Dab (Dab-Br)) and POPC (1-palmitoyl-2-oleoylphosphatidylcholine) model membranes (monolayers and liposomes). The pressure-area isotherms and the compressional modulus of the monolayers revealed that Dab is likely to penetrate the hydrophobic region of POPC, whereas Dab-Br inserts mainly into the lipid headgroup area. This assumption was confirmed by FTIR-ATR of POPC liposomes containing Dab and Dab-Br dendrimers. In addition, Dab induced a higher lipi

SUBMITTER: Jordanova A 

PROVIDER: S-EPMC11991017 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature