Black Phosphorous-Based Surface Plasmon Resonance Biosensor for Malaria Diagnosis.

ABSTRACT: This study presents a black phosphorus-based surface plasmon resonance (SPR) biosensor for malaria detection, integrating silicon nitride (Si₃N₄) and single-stranded DNA (ssDNA) to enhance sensitivity and molecular recognition. The biosensor configurations were optimized through numerical simulations, evaluating metal thickness, dielectric layer thickness, and the number of black phosphorus layers to achieve maximum performance. The optimized system (Opt-Sys₄) exhibited high sensitivity (464.4°/RIU for early-stage malaria) and improved detection accuracy, outperforming conventional SPR sensors. Performance was assessed across malaria progression stages, demonstrating a clear resonance shift, increased attenuation, and enhanced biomolecular interactions. Key

SUBMITTER: Tene T 

PROVIDER: S-EPMC11991473 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature