Associations of alcohol with the human gut microbiome and prospective health outcomes in the FINRISK 2002 cohort.

ABSTRACT:

Background and aims

Alcohol remains a global risk factor for non-communicable diseases with the gut microbiome emerging as a novel elucidator. We investigated how gut microbiome associates with alcohol on population level, if there is mediation reflected in health outcomes, and how functional potential is related.

Methods

Our sample consisted of 4575 shallow-shotgun sequenced fecal samples from the FINRISK 2002 cohort (25-74yrs., 52.5% women). Alcohol (g 100% alcohol/week) use was self-reported. Diversity and differential species abundances were analyzed using multiple linear regression. Compositional differences were analyzed using PERMANOVA, and prospective associations with Cox-regression. Connections between alcohol, microbiome, inflammatory markers, and outcomes were as

SUBMITTER: Koponen K 

PROVIDER: S-EPMC11991935 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature