Development and validation of nomograms for predicting overall survival and cancer-specific survival in unresected colorectal cancer patients undergoing chemotherapy.

ABSTRACT: This study aims to develop nomograms for predicting overall survival (OS) and cancer-specific survival (CSS) in colorectal cancer (CRC) patients who did not receive primary site surgery but underwent chemotherapy. We analyzed data from 3,050 patients treated with chemotherapy without primary site surgery from 2010 to 2015, sourced from the Surveillance, Epidemiology, and End Results (SEER) database. The data were randomly divided into training and validation sets. Initial variable selection was performed using the least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analysis was used to identify independent prognostic factors. Two nomograms were subsequently constructed based on these factors. Survival analysis was conducted using Kaplan-Meier plots and

SUBMITTER: Li YX 

PROVIDER: S-EPMC11992110 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature