Multivalent vaccine candidate from conserved immunogenic peptides in entry or exit proteins of Orthopoxvirus genus.

ABSTRACT: Orthopoxvirus (OPXV) genus includes emerging and re-emerging zoonotic viruses that pose threats to global health. Smallpox caused pandemics in the 20th century. Borealpox was responsible for a death in Alaska in 2024. Mpox, declared a Public Health Emergency by the WHO in 2022, with an alert reclassification in 2024. The lack of effective therapies and the limitations of attenuated virus vaccines, especially for immunocompromised individuals, reinforce the urgent need for new strategies to prevent diseases caused by pathogens of the OPXV genus. This study aimed to identify conserved epitopes in proteins essential for the entry and exit of these viruses and, based on this identification, develop a promising multivalent vaccine candidate. Viral protein sequences were extracted from the NCBI

SUBMITTER: de Araujo LP 

PROVIDER: S-EPMC11992193 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature