Integrative analysis of exosomal ncRNAs and their regulatory networks in liver cancer progression.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a significant global health challenge with complex molecular underpinnings. Recent advancements in understanding the role of non-coding RNAs (ncRNAs) and exosomes in cancer biology have opened new avenues for research into potential diagnostic and therapeutic strategies.

Methods

This study utilized a comprehensive approach to analyze gene expression patterns and regulatory networks in HCC. We integrated RNA sequencing data gathered from both tissue samples and exosomes. The WGCNA and limma R packages were employed to construct co-expression networks and identify differentially expressed ncRNAs, including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs).

Results

Our analysis demonstrated distinct expression profil

SUBMITTER: Mirzaei-Nasab F 

PROVIDER: S-EPMC11992429 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature