Multimodal Neuroimaging as a SUDEP Predictor: What Is Known and What Still Needs to Be Uncovered?

ABSTRACT:

Introduction

Sudden Unexpected Death in Epilepsy (SUDEP) is the most common cause of death in patients with poorly controlled epilepsy. To date, a higher risk of developing SUDEP is mainly identified by clinical factors, among which generalized tonic-clonic seizures and their frequency stand out as part of the highly debated SUDEP-7 Scoring. This review investigates the role of neuroimaging-based approaches as a tool to help predict SUDEP.

Methods

We carried out a systematic search of the literature to identify multimodal neuroimaging modifications (i.e., MRI, fMRI, PET, and SPECT) in patients with epilepsy who died from SUDEP. The following databases were used: PubMed and Google Scholar. The review was registered on the PROSPERO platform (Registration code: CRD42024558765).

SUBMITTER: Quintieri P 

PROVIDER: S-EPMC11992477 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature