Trajectory of Cognitive Function After Incident Heart Failure.

ABSTRACT:

Background

The magnitude of cognitive changes after incident heart failure (HF) is unclear. We assessed whether incident HF is associated with changes in cognition after accounting for pre-HF cognitive trajectories and known determinants of cognition.

Methods

This pooled cohort study included adults without HF, stroke, or dementia from 6 US population-based studies from 1971 to 2019. Linear mixed-effects models estimated cognitive change with incident HF diagnosis and the rate of cognitive change over the years after HF, controlling for pre-HF cognitive trajectories and participant factors. Outcomes included change in global cognition (primary outcome), executive function, and memory (secondary outcomes). Cognitive outcomes were standardized to a t score metric (mean

SUBMITTER: Shore S 

PROVIDER: S-EPMC11992552 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature