Impact of milbemycin oxime on fluconazole resistance in <i>Candida auris</i>.

ABSTRACT:

Background

Candida auris is a pathogenic yeast that can develop resistance to multiple antifungals, particularly to azoles (e.g. fluconazole). Milbemycin oxime potentiates the effect of fluconazole against Candida spp. by inhibiting ABC transporters, such as Cdr1, which is involved in azole drug efflux.

Objectives

This study aimed to assess the interaction of milbemycin oxime and fluconazole against clinical (n = 4) and laboratory-generated (n = 4) C. auris isolates with different mechanisms of azole resistance.

Methods

Interactions of milbemycin oxime and fluconazole were assessed by chequerboard assays and defined as synergistic, indifferent or antagonistic according to the FIC index (FICI) values. The fluorescent substrate rhodami

SUBMITTER: Aubry L 

PROVIDER: S-EPMC11992560 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature