The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.

ABSTRACT:

Introduction

White matter (WM) microstructure is essential for brain function but deteriorates with age and in neurodegenerative conditions such as Alzheimer's disease (AD). Diffusion MRI, enhanced by advanced bi-tensor models accounting for free water (FW), enables in vivo quantification of WM microstructural differences.

Methods

To evaluate how AD genetic risk factors affect limbic WM microstructure - crucial for memory and early impacted in disease - we conducted linear regression analyses in a cohort of 2,614 non-Hispanic White aging adults (aged 50.12 to 100.85 years). The study evaluated 36 AD risk variants across 26 genes, the association between AD polygenic scores (PGSs) and WM metrics, and interactions with cognitive status.

Results

AD PGSs, variants in TMEM

SUBMITTER: Lorenz A 

PROVIDER: S-EPMC11992597 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature