Epinephrine vs Norepinephrine as Initial Treatment in Children With Septic Shock.

ABSTRACT:

Importance

There is no consensus and wide practice variation in the choice of initial vasoactive agent in children with septic shock.

Objective

To determine whether receipt of epinephrine compared with norepinephrine as the first vasoactive medication administered is associated with improved outcomes among children with septic shock without known cardiac dysfunction.

Design, setting, and participants

This single-center, retrospective cohort study used propensity score matching to examine encounters in which a patient was diagnosed with septic shock and required a vasoactive infusion within 24 hours of ED arrival at a freestanding quaternary care children's hospital. Participants included patients aged 1 month to 18 years who presented to the ED and were diagnosed with

SUBMITTER: Eisenberg MA 

PROVIDER: S-EPMC11992602 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature