Recommended approaches for integration of population pharmacokinetic modelling with precision dosing in clinical practice.

ABSTRACT: Current methods of dose determination have contributed to suboptimal and inequitable health outcomes in underrepresented patient populations. The persistent demand to individualise patient treatment, alongside increasing technological feasibility, is leading to a growing adoption of model-informed precision dosing (MIPD) at point of care. Population pharmacokinetic (popPK) modelling is a technique that supports treatment personalisation by characterising drug exposure in diverse patient groups. This publication addresses this important shift in clinical approach, by collating and summarising recommendations from literature. It seeks to provide standardised guidelines on best practices for the development of popPK models and their use in MIPD software tools, ensuring the safeguarding and op

SUBMITTER: Berezowska M 

PROVIDER: S-EPMC11992666 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature