Unveiling the influence of lipidomes on inflammatory bowel disease: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Plasma lipid homeostasis is pivotal in maintaining intestinal health. Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD) as distinct subtypes, manifests unique metabolic signatures. However, the specific roles of lipids in the pathogenesis and therapeutic targeting of IBD remain inadequately explored. This study aims to delineate the genetic influences of plasma lipids on IBD risk.

Methods

We obtained genome-wide association study (GWAS) summary statistics of lipidomes and IBD (including UC and CD) from published studies to perform two-sample Mendelian randomization (MR) analyses. Outliers were removed using radial MR, followed by the application of the inverse-variance weighted (IVW) method to assess causal relationshi

SUBMITTER: Lei H 

PROVIDER: S-EPMC11992711 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature