Bilirubin as a predictor of severity and adverse clinical outcomes of acute ischemic stroke: a systematic review and meta-analysis.

ABSTRACT:

Background

This review aims to comprehensively examine the role of bilirubin in predicting severity and adverse clinical outcomes in patients with acute ischemic stroke (AIS).

Methods

We searched the electronic PubMed, Embase, Scopus, and Web of Science repositories for articles published in English available before the 15th of June 2024. The outcomes assessed were stroke severity, haemorrhagic transformation, symptomatic intracranial haemorrhage (sICH), mortality, and poor functional results.

Results

We analysed data from 13 studies. Our meta-analysis showed that both total bilirubin (RR, 1.10; 95% CI, 1.01-1.19) and direct bilirubin (RR, 1.79; 95% CI, 1.33-2.42) were independently associated with the severity of AIS. Higher quartiles of total bilirubin were associat

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC11992745 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature