Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation.

ABSTRACT:

Background

Pulmonary fibrosis (PF) is an irreversible, progressive, chronic and fatal interstitial lung disease with limited therapeutic options. Dehydrocorydaline (DHC), derived from the traditional Chinese medicinal plant Corydalis yanhusuo, has exhibited a variety of pharmacological properties. Nevertheless, the potential function and mechanism of DHC in the management of PF have yet to be elucidated.

Purpose

To evaluate the therapeutical efficacy of DHC in different PF models and elucidate its underlying mechanism.

Methods

A well-established Bleomycin-induced PF mouse model and human precision-cut lung slices (hPCLS) following fibrosis-inducing cocktail stimulation were employed. The antifibrotic effects of DHC on PF were measured by histopathological manifestatio

SUBMITTER: He J 

PROVIDER: S-EPMC11992754 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature