Predictive potential of combined secretomics and image-based morphometry as a non-invasive method for selecting implanting embryos.

ABSTRACT:

Background

Non-invasive selection of human embryos for in vitro fertilization purposes is still a major challenge to pursue. Therefore, this study aims to identify non-invasive morphometric and secretomic parameters that reliably select the embryos with the highest likelihood of implantation prior to embryo transfer (ET).

Methods

Prospective single-centre cohort study. Thirty-two day 5 blastocysts derived from 28 couples undergoing intracytoplasmic sperm injection (ICSI) and ET between January 2023 and April 2023. Patients were split according to their implantation outcome, confirmed with serum beta-human chorionic gonadotropin (b-hCG) levels > 5 mIU/mL nine days post-SET. Ninety-two proteins involved in embryonic developmental programming were measured in spent blastocyst m

SUBMITTER: Palomar A 

PROVIDER: S-EPMC11992772 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature