Impact of radiation response on survival in pediatric medulloblastoma with residual or disseminated disease.

ABSTRACT:

Background

This study aimed to determine the clinical impact of radiation response on survival in patients with medulloblastoma (MB) and to explore the predictive factor of radiation response.

Methods

Data from 170 pediatric patients with MB and residual disease or metastasis before radiotherapy (RT) were analyzed.

Results

The median follow-up period was 5.2 years. A total of 74 (43.5%) patients achieved CR, 85 (50.0%) patients achieved PR, 8 (4.7%) patients had SD, and 3 (1.8%) patients developed PD after RT. The five-year post-RT progression-free (prtPFS) and overall survival (prtOS) were superior in patients who achieved CR compared to those who did not (prtPFS: 67% ± 6% vs. 42% ± 6%, P < 0.001; prtOS: 82% ± 5% vs. 44% ± 6%, P < 0.001). Multivariable logistic regre

SUBMITTER: Shi X 

PROVIDER: S-EPMC11992783 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature