Association between serum chemokines levels and delayed neurocognitive recovery after non-cardiac surgery in elderly patients: a nested case-control study.

ABSTRACT:

Background

Perioperative neurocognitive disorders encompass delayed neurocognitive recovery (dNCR). Emerging evidence suggests that chemokines play a crucial role in the pathogenesis of various cognitive impairment diseases. However, the association between chemokines and dNCR remains unclear. Therefore, we aimed to investigate the relationship between serum chemokine levels and dNCR in elderly patients undergoing non-cardiac surgery.

Methods

A total of 144 patients undergoing elective major non-cardiac surgery were accessed in neuropsychological testing 1 day prior to and 1 week following the surgery. Blood samples were collected before the initiation of anesthesia and one hour following the cessation of anesthesia. We employed a retrospective nested case-control study desi

SUBMITTER: Han L 

PROVIDER: S-EPMC11992795 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature