ADORA2B promotes proliferation and migration in head and neck squamous cell carcinoma and is associated with immune infiltration.

ABSTRACT:

Background

Adenosine A2B receptor (ADORA2B), a G protein-coupled receptor, is implicated in tumor progression and immune regulation in various cancers. However, its specific role in head and neck squamous cell carcinoma (HNSC) remains largely unexplored. This study aims to elucidate the expression profile, prognostic value, immune modulatory role, and therapeutic potential of ADORA2B in HNSC.

Methods

Comprehensive bioinformatics analyses were performed using TCGA and GEO datasets to evaluate ADORA2B expression, clinical correlations, and prognostic significance in HNSC. Weighted gene co-expression network analysis (WGCNA) and functional enrichment analyses were conducted to explore ADORA2B-associated pathways. Immune infiltration was assessed via ESTIMATE and single-sample g

SUBMITTER: Li P 

PROVIDER: S-EPMC11992813 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature