Disrupting antimicrobial resistance: unveiling the potential of vitamin C in combating biofilm formation in drug-resistant bacteria.

ABSTRACT:

Background

Antimicrobial resistance (AMR) poses a significant threat to global health, exacerbated by the protective mechanisms of biofilms formed by drug-resistant bacteria. Extracellular polymeric substances (EPS) produced by bacteria in biofilms serve as a formidable shield, impeding the efficacy of antimicrobial agents. Here, we investigated the potential of vitamin C (sodium ascorbate) to disrupt biofilm formation in drug-resistant bacteria isolated from diabetic foot ulcer (DFU) patients and studied the antimicrobial and antibiofilm activity of vitamin C on these bacteria.

Results

Out of 117 study isolates, primarily identified as Escherichia coli (n = 52), Staphylococcus spp. (n = 19), and Klebsiella spp. (n = 46), 80 isolates exhibited a Multiple Antimicrobial Resist

SUBMITTER: Rahim S 

PROVIDER: S-EPMC11992815 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature