Moss-derived human complement factor H modulates retinal immune response and attenuates retinal degeneration.

ABSTRACT:

Background

AMD is a multifactorial progressive disease of the central retina that leads to severe vision loss among the elderly. Genome-wide association studies in AMD patients and preclinical data have identified a dysregulated complement system and aberrant microglia responses in the pathogenesis of AMD. Specifically, a genetic variant in the complement factor H (CFH) gene, an important inhibitor of the alternative complement pathway, confers the strongest risk for AMD. Here, we investigated whether moss-derived recombinant human CFH proteins, termed CPV-101 and CPV-104, can modulate microglia reactivity and limit retinal degeneration in a murine light damage paradigm mimicking important features of AMD.

Methods

Two glycosylated human recombinant CFH proteins CPV101, and C

SUBMITTER: Hector M 

PROVIDER: S-EPMC11992837 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature