Insights into the utilisation of 1,2-propanediol and interactions with the cell envelope of Clostridium perfringens.

ABSTRACT:

Background

Breastfeeding is a major determinant of gut microbiota composition and fermentation activity during the first months of life. Breastmilk delivers human milk oligosaccharides (HMO) as substrates for microbial intestinal fermentation. One of the main metabolites that accumulates in feces of breastfed infants is 1,2-propanediol (1,2PD) resulting from the metabolism of fucosylated HMO. 1,2PD is used in microbial cross-feeding to produce propionate, but 1,2PD is also an alcohol that can impact the state of the microbial cell envelope. To shed further light on an understudied compound in the infant gut, we investigated the genetic and metabolic potential of the early gut colonizer Clostridium perfringens to utilise 1,2PD, and the interactions of 1,2PD with the cell envelope.

SUBMITTER: Huertas-Diaz L 

PROVIDER: S-EPMC11992839 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature