Butyrate inhibits histone deacetylase 2 expression to alleviate liver fibrosis in biliary atresia.

ABSTRACT:

Background

Previous studies have found a reduction in butyrate-producing bacteria in the gut microbiota of infants with biliary atresia (BA). Butyrate is also an important inhibitor of histone deacetylase 2 (HDAC2). This study aims to explore how butyrate alleviates liver fibrosis in BA through HDAC2.

Methods

Fibrosis-related pathways associated with butyrate were analyzed using the GSE46960 database. BA liver sections were used to validate factor expression. The effects of HDAC2 and butyrate and the pathway were performed in vitro experiments. Butyrate intervention was performed in bile duct ligation (BDL) mice, and alterations in the gut microbiota were analyzed using fecal 16S rRNA sequencing. The impact of butyrate and related pathways on liver fibrosis in BDL mice was f

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11992845 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature