A single-cell atlas of Schwannoma across genetic backgrounds and anatomic locations.

ABSTRACT:

Background

Schwannomas are nerve sheath tumors arising at cranial and peripheral nerves, either sporadically or in patients with a schwannomatosis-predisposition syndrome. There is limited understanding of the transcriptional heterogeneity of schwannomas across genetic backgrounds and anatomic locations.

Methods

Here, we prospectively profile by single-cell full-length transcriptomics tumors from 22 patients with NF2-related schwannomatosis, non-NF2-related schwannomatosis, and sporadic schwannomas, resected from cranial and peripheral nerves. We profiled 11,373 cells (after QC), including neoplastic cells, fibroblasts, T cells, endothelial cells, myeloid cells, and pericytes.

Results

We characterize the intra-tumoral genetic and transcriptional heterogeneity of schwa

SUBMITTER: Gonzalez Castro LN 

PROVIDER: S-EPMC11992879 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature