Nerve Growth Factor Receptor (NGFR/p75NTR) of the Small-Spotted Catshark (Scyliorhinus canicula): Evolutionary Conservation and Brain Function.

ABSTRACT: The p75NTR receptor, a member of the tumor necrosis factor (TNF) receptor superfamily, can participate in signaling pathways either by forming heteromeric complexes with other receptors, such as the Trk family (tropomyosin receptor kinases), or by functioning independently. p75NTR was investigated prevalently in the brain and retina of mammals, whereas almost nothing is known about its conservation among species. Here, we reconstructed the phylogenetic arb of p75NTR and described for the first time the p75NTR expression in the brain of the basal vertebrate Chondrichthyan Scyliorhinus canicula (S. canicula), uncovering the existing parallelism between ancient vertebrates and mammals. p75NTR functional conservation among vertebrates was further investigated by cloning the S. canicula nerve g

SUBMITTER: Chiavacci E 

PROVIDER: S-EPMC11993139 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature