Efficacy and Safety of Rituximab in Antiglomerular Basement Membrane Disease.

ABSTRACT:

Introduction

Anti-glomerular basement membrane (GBM) disease is caused by pathogenic antibodies usually targeting the noncollagenous domain of the α3 chain of type IV collagen and frequently presents as rapidly progressive glomerulonephritis and diffuse alveolar hemorrhage (DAH). Rapid reduction of these antibodies is imperative for kidney survival and the mainstay of therapy is the combination of plasma exchange (PLEX), glucocorticoids, and cyclophosphamide. Rituximab has been postulated as a potential treatment for anti-GBM disease; however, data on efficacy and safety are lacking.

Methods

We performed a review of case reports and series (n = 28) providing individual patient-level data on the efficacy and safety of rituximab in adult and pediatric anti-GBM disease.

SUBMITTER: Ivkovic V 

PROVIDER: S-EPMC11993202 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature