The Role of Mitochondrial AKT1 Signaling in Renal Tubular Injury of Metabolic Syndrome.

ABSTRACT:

Introduction

Metabolic syndrome (MetS) is increasingly recognized as a contributor to kidney disease, yet the underlying mechanisms remain poorly defined. Recent studies suggest a pivotal role for mitochondrial dysfunction in renal injury. We hypothesized that mitochondrial AKT1 signaling in renal tubules plays a critical role in MetS-related kidney injuries.

Methods

MetS was induced in a 8-week-old C57BL/6 male mice using a high-fat diet (HFD) for 4 months compared with controls on a standard chow diet. Additional experiments were conducted in DB/DB diabetic mice and their controls (WT and DB/WT) to validate findings. Renal metabolic parameters, mitochondrial AKT1 signaling, and markers of kidney injury were assessed.

Results

MetS mice exhibited significant weight ga

SUBMITTER: Lin HY 

PROVIDER: S-EPMC11993225 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature