Using physiologically based models to predict in vivo skeletal muscle energetics.

ABSTRACT: Understanding how muscles use energy is essential for elucidating the role of skeletal muscle in animal locomotion. Yet, experimental measures of in vivo muscle energetics are challenging to obtain, so physiologically based muscle models are often used to estimate energy use. These predictions of individual muscle energy expenditure are not often compared with indirect whole-body measures of energetic cost. Here, we examined and illustrated the capability of physiologically based muscle models to predict in vivo measures of energy use, which rely on fundamental relationships between muscle mechanical state and energy consumption. To improve model predictions and ensure a physiological basis for model parameters, we refined our model to include data from isolated muscle experiments and acco

SUBMITTER: Konno RN 

PROVIDER: S-EPMC11993265 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature