The association between proton pump inhibitors and the risk of gastrointestinal bleeding in oral anticoagulants users.

ABSTRACT: Current evidence of whether proton pump inhibitor (PPI) reduces the risk of gastrointestinal bleeding (GIB) associated with oral anticoagulants (OACs) is limited. Propensity score-weighted cohort and case-crossover studies were conducted separately in England and Hong Kong between 2011.01.01 and 2019.12.31. In the cohort design, we compared the hazards of hospitalised GIB in OAC  +  PPI users with OAC only users in people with atrial fibrillation and found higher hazard of GIB in OAC  +  PPI users in both settings. In the case-crossover design, elevated odds of exposure to PPI only , OAC only and OAC  +  PPI associated with GIB between 30-day hazard and referent per

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11993357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature