Impact of waitlist weight change on outcomes in heart transplant recipients: a UNOS database analysis.

ABSTRACT:

Background

While the effect of pre-transplant weight on patient outcomes following heart transplantation (HTx) has previously been studied, data regarding the impact of dynamic weight change prior to HTx are extremely limited.

Objectives

We sought to elucidate the interaction between HTx listing weight and weight change while waitlisted, and explore how that interaction impacts post-HTx survival in a continuous manner.

Methods

Adult patients listed for HTx from 1987 to 2020 were identified from UNOS database. Three-dimensional restricted cubic spline analysis explored post-HTx survival relative to both changes in BMI/weight and BMI at time of HTx listing. Continuous predictor variables were analyzed with Cox proportional hazards method.

Results

9,628 included p

SUBMITTER: Austin MA 

PROVIDER: S-EPMC11993457 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature