Impact of corticosteroid withdrawal on bone mineral density after kidney transplantation.

ABSTRACT:

Background

Bone abnormalities are common after kidney transplantation (KTx) and are associated with an increased risk of fractures. The pathophysiology of post-KTx bone disorders is multifactorial, with corticosteroid (CS) therapy being a contributor to the loss of bone mineral density (BMD). This study aimed to evaluate the impact of CS withdrawal versus continued CS therapy on BMD evolution in a kidney transplant recipients (KTRs) cohort.

Methods

We retrospectively analyzed BMD data from 132 patients who underwent KTx between 2005 and 2021. BMD was assessed using dual-energy X-ray absorptiometry at the time of KTx (T0) and two-years post-KTx (2yT). Patients were categorized into two groups: those who discontinued CS (CS-) within the first-year post KTx and those who contin

SUBMITTER: Bouquegneau A 

PROVIDER: S-EPMC11993465 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature