Efficacy of maintenance or consolidation therapy for multiple myeloma based on proteasome inhibitors: a meta-analysis.

ABSTRACT:

Background

This study assessed the efficacy of proteasome inhibitors (PIs) in both maintenance and consolidation therapies for MM patients.

Methods

A comprehensive search across multiple databases was conducted, including PubMed, Science Direct, Google Scholar, CNKI, EMBASE, Web of Science, MEDLINE, Cochrane Library, and others, to identify randomized controlled trials published in both Chinese and English languages that examined the use of PIs in either consolidation or maintenance therapy for multiple myeloma. The effectiveness outcomes assessed included complete response (CR), very good partial response or better (≥ VGPR), partial response (PR), progression-free survival (PFS), and overall survival (OS).

Results

Our analysis comprised four (4) randomized controlled

SUBMITTER: Wu D 

PROVIDER: S-EPMC11993517 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature