Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma.

ABSTRACT:

Purpose

Liver cancer, also known as hepatocellular carcinoma (HCC), is one of the most prevalent and lethal malignancies in the world. The management of HCC depends on the underlying hepatic function and histological stage of the neoplasm, potentially encompassing locoregional therapies, surgical resection, hepatic transplantation, targeted drug therapies, and immunotherapy. However, the outlook for advanced HCC remains poor, with global 5-year survival rates below 15%. Consequently, it is imperative to identify novel tumor biomarkers for HCC prediction.

Methods

Multiple public databases were used to analyze PTBP2 expression, potential biological functions, and immune infiltration levels in HCC. In addition, immunohistochemical staining, phenotypic experiments, flow cytometr

SUBMITTER: Li Y 

PROVIDER: S-EPMC11993520 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature