Real-World Use, Effectiveness, and Safety of Intravenous Fosfomycin: The FORTRESS Study.

ABSTRACT:

Introduction

Intravenous fosfomycin (FOS) is a broad-spectrum antibiotic primarily used in combination therapy to treat severe infections caused by both Gram-positive (GP) and Gram-negative (GN) pathogens, including multi-drug resistant (MDR) bacteria. The aim of this study, the largest to date, was to evaluate the effectiveness, safety, usage patterns, and patient characteristics of FOS in a real-world setting.

Methods

Interim analysis of an ongoing, prospective, non-interventional, multicentre study in five European countries, involving centres in Germany, Italy, the United Kingdom, Greece, and Austria.

Results

A total of 716 patients were enrolled between January 2017 and November 2023 (mean age: 62.8 years, APACHE II: 18.3, SOFA: 6.7). Main indications for FOS wer

SUBMITTER: Bodmann KF 

PROVIDER: S-EPMC11993532 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature