Optogenetic stimulation of inferior colliculus neurons elicits mesencephalic locomotor region activity and reverses haloperidol-induced catalepsy in rats.

ABSTRACT: The inferior colliculus (IC) represents a pivotal midbrain area involved in processing sensory/emotional facets of auditory stimuli, potentially influencing motor responses. Our prior investigations showed that electric or chemical stimulation of the IC ameliorates haloperidol-induced catalepsy, a manifestation of Parkinsonism in animals. We hypothesized that this amelioration stems from a sensory-motor gating mechanism via IC activation of the mesencephalic locomotor region (MLR). Aiming to investigate this hypothesis, we performed IC optogenetic stimulation and electrophysiological recordings of MLR neuronal activity in anesthetized rats. Additionally, we examined whether optogenetic manipulation of IC could improve motor deficits and affect emotional states in awake rats. Electrophysiol

SUBMITTER: Pochapski JA 

PROVIDER: S-EPMC11993560 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature