Interplay between MRI radiomics and immune gene expression signatures in oral squamous cell carcinoma.

ABSTRACT: With the advances in immunotherapy and the challenge of poor responsiveness in oral squamous cell carcinoma (OSCC) patients, understanding the tumor microenvironment is crucial. Radiogenomics offers the potential to provide pre-operative, non-invasive image-derived immune biomarkers. To this aim, the present study explores the capability of MRI-based radiomics to describe patients' immune state in OSCC. Seven MRI-based radiomic, 29 immune-related gene expression signatures were computed and deconvolution analysis was performed for a subset of OSCC from the BD2Decide database. A correlation-driven analysis identified key associations between radiomic and immune-related signatures and cell populations. Radiomic classifiers of the gene expression signatures were then developed to evaluate the

SUBMITTER: Corti A 

PROVIDER: S-EPMC11993570 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature