Integrated serological surveillance for neglected tropical diseases, vaccine-preventable diseases, and arboviruses in Samoa, 2018.

ABSTRACT: Multiplex bead immunoassays (MBA) can detect antibody responses to multiple antigens. Using MBA data from the Surveillance and Monitoring to Eliminate Lymphatic Filariasis (LF) and Scabies from Samoa (SaMELFS) 2018, we aim to estimate national seroprevalence of neglected tropical diseases (NTDs), vaccine-preventable diseases (VPDs), and arboviruses in Samoa. A community-based serosurvey of 3851 participants aged ≥ 5 years in 35 primary sampling units (PSUs). Using MBA, dried blood spots were assayed for antibodies (Ab) from 10 pathogens: LF, trachoma, yaws, tetanus, diphtheria, rubella, measles, dengue, Zika, and chikungunya. Seroprevalence was adjusted for study design, age, and gender. NTD seroprevalence for LF was 50.8% (Bm33 Ab), 32.0% (Wb123 Ab), 20.3% (Bm14 Ab); 5.5% for trachoma; an

SUBMITTER: Lawford HLS 

PROVIDER: S-EPMC11993588 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature