Probing the molecular mechanism of kaempferol in relieving rheumatoid arthritis based on network pharmacology.

ABSTRACT: Kaempferol is an active compound found in traditional Chinese medicine epimedium soup, which exhibits potent anti-inflammatory and antioxidant properties. Nevertheless, the mechanism of action in rheumatoid arthritis remains unclear. This study constructed targets protein interaction networks by utilizing the String platform. The analysis of GO function and kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment was performed on key target genes. Target gene validation was conducted through microarray analysis. Molecular docking was employed to evaluate the relationship between kaempferol and various key targets. In vitro experiments were conducted to elucidate kaempferol's mechanism of action on rheumatoid arthritis. Topological analysis of the protein protein interaction (PPI)

SUBMITTER: Liu H 

PROVIDER: S-EPMC11993661 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature