Indirect calorimetry and nitrogen balance guided nutrition therapy in ICU patients with acute kidney injury.

ABSTRACT: Data on the benefits of early integration of indirect calorimetry (IC) for caloric guidance and maintaining a positive nitrogen balance in critically ill patients with acute kidney injury (AKI) are scarce. This study aimed to evaluate the impact of the nutritional therapeutic approach on mortality and renal outcomes in these patients. We conducted an open-label randomized controlled trial, Intensive Care Unit (ICU)-admitted patients on mechanical ventilation who were diagnosed with AKI within 72 h after admission were enrolled and assigned to receive either early goal nutrition therapy (caloric dosing guided by IC and protein delivery guided by nitrogen balance, maximum 1.3 g/kg/day) or conventional nutrition therapy for 14 days. The primary outcome was all-cause 28-day mortality. Secondar

SUBMITTER: Jeerangsapasuk W 

PROVIDER: S-EPMC11993687 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature