Type I collagen secreted in white matter lesions inhibits remyelination and functional recovery.

ABSTRACT: White matter injury is caused by cerebral blood flow disturbances associated with stroke and demyelinating diseases such as multiple sclerosis. Remyelination is induced spontaneously after white matter injury, but progressive multiple sclerosis and white matter stroke are usually characterised by remyelination failure. However, the mechanisms underlying impaired remyelination in lesions caused by demyelination and stroke remain unclear. In the current study, we demonstrated that collagen fibres accumulated in the demyelinated lesions of multiple sclerosis patients (age range 23-80 years) and white matter lesions of stroke patients (age range 80-87 years), suggesting that the accumulation of collagen fibres correlates with remyelination failure in these lesions. To investigate the function

SUBMITTER: Yamazaki R 

PROVIDER: S-EPMC11993711 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature