Optimization of glutaraldehyde concentration in relation to swelling behavior of PVA-PEG-BTB film using hybrid genetic metaheuristic algorithm.

ABSTRACT: The crosslinking characteristics of hydrogels and polymeric films critically influence their swelling capacity, a key factor in wound care applications. This study optimized the swelling behavior of polyvinyl alcohol (PVA)-polyethylene glycol (PEG)-bromothymol blue (BTB) films using three hybrid metaheuristic algorithms: Hybrid Genetic-Hippopotamus Optimizer (HG-HO), Hybrid Genetic-Walrus Optimization Algorithm (HG-WOA), and Hybrid Genetic-Horned Lizard Optimization Algorithm (HG-HLOA). Among these, HG-HLOA achieved the fastest convergence, while all algorithms reliably identified optimal solutions with comparable fitness values. The optimal glutaraldehyde concentration was determined as 4.9251 wt%, with a predicted maximum swelling ratio of 1217.7311%. Experimental validation yielded an a

SUBMITTER: Kim D 

PROVIDER: S-EPMC11993761 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature